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Antibiotic-resistant Escherichia coli isolated from urban rodents in Hanoi, Vietnam.

Authors :
LE Huy H
Koizumi N
Ung TTH
LE TT
Nguyen HLK
Hoang PVM
Nguyen CN
Khong TM
Hasebe F
Haga T
LE MTQ
Hirayama K
Miura K
Source :
The Journal of veterinary medical science [J Vet Med Sci] 2020 May 20; Vol. 82 (5), pp. 653-660. Date of Electronic Publication: 2020 Mar 30.
Publication Year :
2020

Abstract

Antimicrobial resistance (AMR) is a global public health concern for both clinical and veterinary medicine. Rodent feces are one of the major infectious sources of zoonotic pathogens including AMR bacteria. So far, there are limited studies reported focused on Escherichia coli isolated in rodent feces from rural and suburban areas in Vietnam. In this study, we investigated the prevalence of antimicrobial resistance in E. coli isolated from feces samples of 144 urban rodents caught in Hanoi, Vietnam. A total of 59 AMR E. coli was isolated from urban rodents of which 42 were multidrug-resistant (MDR) isolates (resistance to at least three classes of antimicrobial agents), four were extended-spectrum β-lactamase (ESBL) producing isolates and five were colistin-resistant isolates. The highest prevalence of the resistance was against ampicillin (79.7%: 47/59), followed by tetracycline (78.0%: 46/59), nalidixic acid (67.8%: 40/59), sulfamethoxazole-trimethoprim (59.3%: 35/59), chloramphenicol (45.8%: 27/59), ciprofloxacin (44.1%: 26/59), cefotaxime (30.5%: 18/59), cefodizime (23.7%: 14/59), amoxicillin-clavulanate (22.0%: 13/59), and gentamicin (22.0%: 13/59). With regard to the virulence genes associated with diarrheagenic E. coli (DEC), only aaiC gene found in one AMR isolate. In general, the use of antimicrobials does not aim to treat rodents except for companion animals. However, our findings show the carriage of AMR and MDR E. coli in urban rodents and highlight the potential risk of rodents in Hanoi acting as a reservoir of transferable MDR E. coli, including ESBL-producing, colistin-resistant E. coli, and virulence-associated with DEC.

Details

Language :
English
ISSN :
1347-7439
Volume :
82
Issue :
5
Database :
MEDLINE
Journal :
The Journal of veterinary medical science
Publication Type :
Academic Journal
Accession number :
32224554
Full Text :
https://doi.org/10.1292/jvms.19-0697