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MAML2 rearrangement as a useful diagnostic marker discriminating between Warthin tumour and Warthin-like mucoepidermoid carcinoma.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2020 Sep; Vol. 477 (3), pp. 393-400. Date of Electronic Publication: 2020 Mar 28. - Publication Year :
- 2020
-
Abstract
- Warthin tumour is the second most common benign neoplasm of salivary glands. Despite its relatively characteristic histology, it may sometimes mimic other lesions. Here, we report two female non-smoker patients diagnosed with low-grade mucoepidermoid carcinoma with oncocytic epithelium and prominent lymphoid (Warthin-like) stroma and with molecularly confirmed MAML2 rearrangement. In addition, we screened a consecutive series of 114 Warthin tumour cases by means of MAML2 break apart fluorescence in situ hybridization to assess its value in differential diagnosis. MAML2 rearrangement was detected in both mucoepidermoid carcinoma cases, while all Warthin tumours were negative. Taking into account the literature data, Warthin-like mucoepidermoid carcinomas are more frequently observed in women, while a slight male predominance and smoking history are typical for Warthin tumour. In addition, the patients with Warthin-like mucoepidermoid carcinoma were significantly younger than those with Warthin tumour. To conclude, Warthin-like mucoepidermoid carcinoma may usually be suspected based on histology, while the diagnosis can be confirmed by means of molecular assays such as FISH. The investigation of MAML2 status is particularly advised when Warthin tumour is considered in a young, non-smoking, female patient.
- Subjects :
- Adenolymphoma genetics
Adenolymphoma pathology
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor genetics
Carcinoma, Mucoepidermoid genetics
Carcinoma, Mucoepidermoid pathology
DNA-Binding Proteins genetics
Diagnosis, Differential
Female
Gene Fusion
Gene Rearrangement
Humans
Male
Middle Aged
Nuclear Proteins genetics
Salivary Glands pathology
Transcription Factors genetics
Adenolymphoma diagnosis
Carcinoma, Mucoepidermoid diagnosis
Trans-Activators genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2307
- Volume :
- 477
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 32222825
- Full Text :
- https://doi.org/10.1007/s00428-020-02798-5