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Comparison of [ 68 Ga]Ga-DOTA-FAPI-04 and [ 18 F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer.
- Source :
-
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2020 Jul; Vol. 47 (8), pp. 1820-1832. Date of Electronic Publication: 2020 Mar 28. - Publication Year :
- 2020
-
Abstract
- Purpose: We evaluated the potential usefulness of [ <superscript>68</superscript> Ga]Ga-DOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various types of cancer, compared with [ <superscript>18</superscript> F] FDG PET/CT.<br />Methods: A total of 75 patients with various types of cancer underwent contemporaneous [ <superscript>68</superscript> Ga]Ga-DOTA-FAPI-04 and [ <superscript>18</superscript> F] FDG PET/CT either for an initial assessment or for recurrence detection. Tumour uptake was quantified by the maximum standard uptake value (SUV <subscript>max</subscript> ). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of [ <superscript>18</superscript> F] FDG and [ <superscript>68</superscript> Ga]Ga-DOTA-FAPI-04 PET/CT were calculated and compared to evaluate the diagnostic efficacy.<br />Results: The study cohort consisted of 75 patients (47 males and 28 females; median age, 61.5 years; age range, 32-85 years). Fifty-four patients with 12 different tumour entities underwent paired [ <superscript>68</superscript> Ga]Ga-DOTA-FAPI-04 and [ <superscript>18</superscript> F] FDG PET/CT for initial assessment, while the other 21 patients underwent paired scans for recurrence detection. [ <superscript>68</superscript> Ga]Ga-DOTA-FAPI-04 PET/CT was able to clearly identify 12 types of malignant tumours with favourable tumour-to-background contrast, which resulted in a higher detection rate of primary tumours than did [ <superscript>18</superscript> F] FDG PET/CT (98.2% vs. 82.1%, P = 0.021). Meanwhile, [ <superscript>68</superscript> Ga]Ga-DOTA-FAPI-04 PET/CT showed a better sensitivity than [ <superscript>18</superscript> F] FDG PET/CT in the detection of lymph nodes (86.4% vs. 45.5%, P = 0.004) and bone and visceral metastases (83.8% vs. 59.5%, P = 0.004).<br />Conclusion: [ <superscript>68</superscript> Ga]Ga-DOTA-FAPI-04 PET/CT showed a superior diagnostic efficacy than [ <superscript>18</superscript> F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer, especially in identifying liver metastases, peritoneal carcinomatosis, and brain tumours.
Details
- Language :
- English
- ISSN :
- 1619-7089
- Volume :
- 47
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of nuclear medicine and molecular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 32222810
- Full Text :
- https://doi.org/10.1007/s00259-020-04769-z