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Pesimquinolones produced by Penicillium simplicissimum and their inhibitory activity on nitric oxide production.
- Source :
-
Phytochemistry [Phytochemistry] 2020 Jun; Vol. 174, pp. 112327. Date of Electronic Publication: 2020 Mar 26. - Publication Year :
- 2020
-
Abstract
- Eight undescribed quinolone alkaloids, pesimquinolones A-H, as well as six known compounds, were isolated from the solid culture broth of the fungus Penicillium simplicissimum. Their chemical structures were characterized by combined analyses of NMR spectroscopy and single-crystal X-ray crystallography. Pesimquinolones A-G are the first examples of naturally occurring quinolone alkaloids possessing a limonene moiety. Their anti-inflammatory activities on LPS-induced nitric oxide (NO) production in adherent cells were evaluated. Pesimquinolones A, E, G, and H showed promising suppressive effect on the production of NO with IC <subscript>50</subscript> values of 1.94, 1.29, 1.20, and 1.23 μM, respectively.<br /> (Copyright © 2020. Published by Elsevier Ltd.)
- Subjects :
- Anti-Inflammatory Agents
Molecular Structure
Nitric Oxide
Alkaloids
Penicillium
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 174
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32222549
- Full Text :
- https://doi.org/10.1016/j.phytochem.2020.112327