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Advances in understanding the potential therapeutic applications of gut microbiota and probiotic mediated therapies in celiac disease.
- Source :
-
Expert review of gastroenterology & hepatology [Expert Rev Gastroenterol Hepatol] 2020 May; Vol. 14 (5), pp. 323-333. Date of Electronic Publication: 2020 Mar 27. - Publication Year :
- 2020
-
Abstract
- Introduction: Celiac Disease (CD) is an autoimmune enteropathy caused by exposure to gluten in genetically predisposed people. While gluten is the main driving force in CD, evidence has shown that microbiota might be involved in the pathogenesis, development, and clinical presentation of CD. Microbiota manipulation may modify its functional capacity and may be crucial for setting-up potential preventive or therapeutic application. Moreover, probiotics are an excellent source of endopeptidases for digesting gluten.<br />Areas Covered: In this narrative review we illustrate all the recent scientific discoveries in this field including CD pathogenetic mechanism where gut microbiota might be involved and possible use of probiotics in CD prevention and treatment.<br />Expert Opinion: In the future, probiotics could be used as an add-on medication for strengthening/facilitating the gluten-free diet (GFD) and improving symptoms; the prospect of using it for therapeutic purposes is to be sought in a more distant future.
- Subjects :
- Celiac Disease genetics
Celiac Disease immunology
Celiac Disease microbiology
Diet, Gluten-Free
Dysbiosis immunology
Dysbiosis metabolism
Dysbiosis microbiology
Endopeptidases analysis
Endopeptidases metabolism
Endopeptidases therapeutic use
Fermentation
Gastrointestinal Microbiome genetics
Gastrointestinal Microbiome immunology
Gene-Environment Interaction
Genetic Predisposition to Disease
Glutens adverse effects
Glutens immunology
Glutens metabolism
Humans
Probiotics chemistry
Risk Factors
Triticum metabolism
Celiac Disease therapy
Dysbiosis therapy
Gastrointestinal Microbiome physiology
Probiotics therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1747-4132
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Expert review of gastroenterology & hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 32216476
- Full Text :
- https://doi.org/10.1080/17474124.2020.1745630