Back to Search Start Over

Brazilian native fruit extracts act as preventive agents modulating the purinergic and cholinergic signalling in blood cells and serum in a rat model of metabolic syndrome.

Authors :
Oliveira PS
Soares MSP
Bona NP
da Silva PG
Mendonça LT
Vieira A
Dal-Pizzol F
Vizzotto M
Lencina CL
Spanevello RM
Stefanello FM
Source :
Archives of physiology and biochemistry [Arch Physiol Biochem] 2022 Aug; Vol. 128 (4), pp. 993-1000. Date of Electronic Publication: 2020 Mar 26.
Publication Year :
2022

Abstract

In this study, we evaluated the effects of native fruit extracts on inflammatory and thromboregulatory parameters in animal model of metabolic syndrome (MetS) induced by highly palatable diet (HPD). Rats were divided into 4 experimental groups: standard chow, HPD, HPD and Psidium cattleianum extract, and HPD and Eugenia uniflora extract. HPD increased serum interleukin-6 (IL-6) levels. On the other hand, this change was prevented by extracts. HPD decreased NTPDase activity in lymphocytes and platelets and 5'-nucleotidase in platelets. Treatment with extracts prevented these changes. An increase in adenosine deaminase (ADA) activity was prevented by E. uniflora in lymphocytes and serum of rats. Fruit extracts prevented the increase in the activity of acetylcholinesterase (AChE) in lymphocytes and butyrylcholinesterase (BuChE) in serum induced by the HPD. Brazilian native fruit extracts have anti-inflammatory and antithrombotic effects, demonstrating therapeutic potential in the prevention of complications associated with MetS.

Details

Language :
English
ISSN :
1744-4160
Volume :
128
Issue :
4
Database :
MEDLINE
Journal :
Archives of physiology and biochemistry
Publication Type :
Academic Journal
Accession number :
32212985
Full Text :
https://doi.org/10.1080/13813455.2020.1743723