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Anatomy of a viral entry platform differentially functionalized by integrins α3 and α6.
- Source :
-
Scientific reports [Sci Rep] 2020 Mar 24; Vol. 10 (1), pp. 5356. Date of Electronic Publication: 2020 Mar 24. - Publication Year :
- 2020
-
Abstract
- During cell invasion, human papillomaviruses use large CD151 patches on the cell surface. Here, we studied whether these patches are defined architectures with features for virus binding and/or internalization. Super-resolution microscopy reveals that the patches are assemblies of closely associated nanoclusters of CD151, integrin α3 and integrin α6. Integrin α6 is required for virus attachment and integrin α3 for endocytosis. We propose that CD151 organizes viral entry platforms with different types of integrin clusters for different functionalities. Since numerous viruses use tetraspanin patches, we speculate that this building principle is a blueprint for cell-surface architectures utilized by viral particles.
- Subjects :
- Actins metabolism
Cell Line
Humans
Integrin alpha3 genetics
Integrin alpha6 genetics
Keratinocytes virology
Papillomavirus Infections pathology
Papillomavirus Infections virology
Tetraspanin 24 metabolism
Virion metabolism
Virion pathogenicity
Host-Pathogen Interactions physiology
Human papillomavirus 16 pathogenicity
Integrin alpha3 metabolism
Integrin alpha6 metabolism
Virus Internalization
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32210347
- Full Text :
- https://doi.org/10.1038/s41598-020-62202-9