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Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography.
- Source :
-
Scientific reports [Sci Rep] 2020 Mar 24; Vol. 10 (1), pp. 5255. Date of Electronic Publication: 2020 Mar 24. - Publication Year :
- 2020
-
Abstract
- Spectral-domain optical coherence tomography (SD-OCT) represents a reliable tool for retinal layer volume and thickness measurement. The aim of this study was to evaluate retinal changes indicating neurodegenerative processes in patients with end-stage renal disease (ESRD) compared to healthy controls. This was a cross-sectional, single-center study comprising 32 ESRD patients and 38 controls. Sectoral retinal nerve fiber layer (RNFL) thickness and retinal layer volumes were obtained by SD-OCT. Age- and gender-adjusted retinal layer volumes such as total retinal volume (p = 0.037), ganglion cell layer volume (GCL, p = 0.003), ganglion cell layer - inner plexiform layer volume (GCL-IPL, p = 0.005) and inner retinal layer volume (IRL, p = 0.042) of the right eye were lower in ESRD patients. Inner plexiform layer volume of both eyes (IPL, right eye: p = 0.017; left eye: 0.044) was reduced, as was RNFL thickness in the temporal superior sector (right eye: p = 0.016). A subgroup analysis excluding patients with diabetes revealed that GCL (p = 0.014) and GCL-IPL volume of the right eye (p = 0.024) and temporal superior sector of the RNFL scan (p = 0.021) in ESRD patients were still significantly thinner. We observed a decrease in several retinal layer volumes and temporal RNFL thickness indicative of retinal neurodegenerative processes in patients with ESRD.
- Subjects :
- Case-Control Studies
Cross-Sectional Studies
Diabetic Nephropathies complications
Diabetic Nephropathies therapy
Diabetic Retinopathy complications
Diabetic Retinopathy diagnostic imaging
Diabetic Retinopathy pathology
Female
Glycated Hemoglobin analysis
Hematocrit
Hemoglobins analysis
Humans
Kidney Failure, Chronic pathology
Kidney Failure, Chronic therapy
Lipids blood
Male
Middle Aged
Nerve Fibers ultrastructure
Optic Nerve pathology
Renal Dialysis
Retina pathology
Retinal Degeneration blood
Retinal Degeneration diagnostic imaging
Retinal Degeneration pathology
Retinal Ganglion Cells pathology
Kidney Failure, Chronic complications
Optic Nerve diagnostic imaging
Retina diagnostic imaging
Retinal Degeneration etiology
Tomography, Optical Coherence methods
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32210247
- Full Text :
- https://doi.org/10.1038/s41598-020-61308-4