Back to Search
Start Over
Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance.
- Source :
-
Trends in cancer [Trends Cancer] 2020 Apr; Vol. 6 (4), pp. 319-336. Date of Electronic Publication: 2020 Feb 19. - Publication Year :
- 2020
-
Abstract
- Circular RNA (circRNA) is a class of single-stranded molecules with tissue/development-specific expression patterns. Unlike linear RNA, circRNA forms a covalently closed loop produced from 'back-splicing' of primary transcripts, conferring on them inherent resistance to exonucleolytic RNA decay. Increasing evidence demonstrates that many circRNAs exert important biological functions by acting as miRNA inhibitors ('sponges'), protein 'decoys', or by encoding small peptides. Importantly, circRNAs are aberrantly expressed in cancer and play indispensable oncogenic or tumor suppressive roles during tumor development and progression. In this review, we summarize the biogenesis, turnover, and involvements of circRNAs in cancer and also discuss their potential as diagnostic biomarkers or therapeutic targets.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents therapeutic use
Biomarkers, Tumor agonists
Biomarkers, Tumor antagonists & inhibitors
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Carcinogenesis drug effects
Carcinogenesis genetics
Disease Progression
Genes, Tumor Suppressor
Humans
Mice
MicroRNAs metabolism
Neoplasms diagnosis
Neoplasms drug therapy
Oncogenes genetics
RNA Precursors genetics
RNA Splicing
RNA Stability
RNA, Circular chemistry
RNA, Circular genetics
RNA, Small Interfering pharmacology
RNA, Small Interfering therapeutic use
Xenograft Model Antitumor Assays
Antineoplastic Agents pharmacology
Gene Expression Regulation, Neoplastic drug effects
Neoplasms genetics
RNA, Circular metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2405-8025
- Volume :
- 6
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Trends in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32209446
- Full Text :
- https://doi.org/10.1016/j.trecan.2020.01.012