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Nanotherapeutics for Immuno-Oncology: A Crossroad for New Paradigms.
- Source :
-
Trends in cancer [Trends Cancer] 2020 Apr; Vol. 6 (4), pp. 288-298. Date of Electronic Publication: 2020 Feb 13. - Publication Year :
- 2020
-
Abstract
- With the rapid increase in the use of nanotechnology and immunotherapy for cancer management in the recent past, there are great implications for using nanotechnology in immuno-oncology. However, to deliver clinical success, the scientific and clinical rationale must be critically evaluated when applying nanotechnology to immuno-oncology challenges. This opinion article distinguishes between designing nanotherapeutics for immunotherapy and the past focus on the placement of chemotherapy agents in nanoparticles. We believe the integration of nanotechnology with cancer immunotherapy for nano-immunotherapeutics provides unique opportunities for both fields, paving the way for entirely new therapeutic paradigms. As a particular focus in our article, we envision the necessities and challenges of nanotechnology in the development of in situ cancer vaccines, immune checkpoint inhibitors, adoptive cell transfer, and bispecific antibody therapy.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Antibodies, Bispecific administration & dosage
Cancer Vaccines administration & dosage
Drug Carriers chemistry
Drug Compounding methods
Drug Compounding trends
Humans
Immune Checkpoint Inhibitors administration & dosage
Immunotherapy, Adoptive methods
Medical Oncology methods
Nanoparticles chemistry
Neoplasms immunology
Allergy and Immunology trends
Medical Oncology trends
Nanomedicine methods
Nanoparticles therapeutic use
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2405-8025
- Volume :
- 6
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Trends in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32209444
- Full Text :
- https://doi.org/10.1016/j.trecan.2020.01.011