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Relationship between impaired parasympathetic vasodilation and hyposalivation in parotid glands associated with type 2 diabetes mellitus.
- Source :
-
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2020 May 01; Vol. 318 (5), pp. R940-R949. Date of Electronic Publication: 2020 Mar 25. - Publication Year :
- 2020
-
Abstract
- We examined the relationship between hemodynamics in the three major salivary glands and salivary secretion in urethane-anesthetized and sympathectomized type 2 diabetic and nondiabetic rats via laser speckle imaging and by collecting the saliva. Lingual nerve stimulation elicited rapid increases in glandular blood flow and induced salivary secretion from the three glands in both diabetic and nondiabetic rats. In the parotid gland, the magnitude of blood flow increase and salivary secretion was significantly lower in the diabetic rats when compared with the nondiabetic rats; however, this was not observed in the other glands. Although the intravenous administration of acetylcholine increased blood flow in the parotid gland in a dose-dependent manner, the response was significantly lower in the diabetic rats when compared with the nondiabetic rats. Similarly, mRNA expression levels of M1 and M3 muscarinic acetylcholine receptors in the parotid gland were relatively lower in the diabetic rats compared with the nondiabetic rats. Our results indicate that type 2 diabetes impairs parasympathetic vasodilation and salivary secretion in the parotid gland and suggest that disturbances in the cholinergic vasodilator pathway may contribute to the underlying mechanisms involved in the disruption of parasympathetic nerve-mediated glandular vasodilation.
- Subjects :
- Animals
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 genetics
Diabetes Mellitus, Type 2 metabolism
Diabetic Neuropathies etiology
Diabetic Neuropathies genetics
Diabetic Neuropathies metabolism
Disease Models, Animal
Down-Regulation
Male
Parotid Gland metabolism
Rats, Inbred OLETF
Receptor, Muscarinic M1 genetics
Receptor, Muscarinic M1 metabolism
Receptor, Muscarinic M3 genetics
Receptor, Muscarinic M3 metabolism
Xerostomia etiology
Xerostomia genetics
Xerostomia metabolism
Diabetes Mellitus, Type 2 physiopathology
Diabetic Neuropathies physiopathology
Parasympathetic Nervous System physiopathology
Parotid Gland blood supply
Parotid Gland physiopathology
Salivation
Vasodilation
Xerostomia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1490
- Volume :
- 318
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Regulatory, integrative and comparative physiology
- Publication Type :
- Academic Journal
- Accession number :
- 32209022
- Full Text :
- https://doi.org/10.1152/ajpregu.00016.2019