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MicroRNA-19a-3p regulates cell growth through modulation of the PIK3IP1-AKT pathway in hepatocellular carcinoma.
- Source :
-
Journal of Cancer [J Cancer] 2020 Feb 10; Vol. 11 (9), pp. 2476-2484. Date of Electronic Publication: 2020 Feb 10 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- There are some controversies about the involvement of microRNA (miR)-19a-3p in hepatocellular carcinoma (HCC) biology, even though many studies have shown that it plays an important role in cancer. In this study, we found that miR-19a-3p is usually overexpressed in HCC tissues compared with corresponding peritumorous tissues, and its expression was associated with tumor size and poor overall survival. MiR-19a-3p promoted cell proliferation significantly, and more cells were found in the S phase. In vivo, miR-19a-3p promoted liver tumor growth, and more HCC cells were found in the active cell cycle. Sequencing and bioinformatics analysis predicted that PIK3IP1 is a likely target gene of miR-19a-3p, and we next confirmed it by luciferase and rescue assays. Altogether, our data showed an important role of PIK3IP1 downregulation by miR-19a-3p in HCC progression, and the miR-19a-3p-PIK3IP1-AKT pathway may be a potential therapeutic target.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.<br /> (© The author(s).)
Details
- Language :
- English
- ISSN :
- 1837-9664
- Volume :
- 11
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32201518
- Full Text :
- https://doi.org/10.7150/jca.37748