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Feasibility of using dynamic contrast-enhanced MRI for differentiating thymic carcinoma from thymic lymphoma based on semi-quantitative and quantitative models.
- Source :
-
Clinical radiology [Clin Radiol] 2020 Jul; Vol. 75 (7), pp. 560.e19-560.e25. Date of Electronic Publication: 2020 Mar 17. - Publication Year :
- 2020
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Abstract
- Aim: To evaluate the value of using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) derived parameters to differentiate thymic carcinoma and thymic lymphoma based on semi-quantitative and quantitative models.<br />Materials and Methods: Twenty-nine pathologically confirmed anterior mediastinum tumours in 29 patients were enrolled in this retrospective study, including 15 thymic carcinoma and 14 lymphoma patients. All the patients underwent pre-treatment mediastinum DCE-MRI. Both semi-quantitative and quantitative parameters were calculated and the volume transfer constant K <superscript>trans</superscript> , the flux rate constant between extravascular extracellular space and plasma k <subscript>ep</subscript> , the extravascular extracellular volume fraction v <subscript>e</subscript> were obtained based on a modified Tofts model. DCE-MRI derived parameters were compared between thymic carcinoma and thymic lymphoma groups.<br />Results: Thymic carcinoma had significantly lower k <subscript>ep</subscript> (p=0.040) and higher v <subscript>e</subscript> (p=0.018) than thymic lymphoma; however, there were no significant differences on K <superscript>trans</superscript> and semi-quantitative parameters between the two groups. v <subscript>e</subscript> had the highest area under the curve (cut-off value, 0.282; area under the curve, 0.748; sensitivity, 71.4%; specificity, 80%). The combination of k <subscript>ep</subscript> and v <subscript>e</subscript> could increase the diagnostic performance significantly (area under the curve, 0.752; sensitivity, 57.1%; specificity, 93.3%).<br />Conclusion: DCE-MRI derived parameters may have value in the differentiating thymic carcinoma and thymic lymphoma.<br /> (Copyright © 2020. Published by Elsevier Ltd.)
- Subjects :
- Adult
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Sensitivity and Specificity
Thymoma diagnosis
Thymus Gland diagnostic imaging
Thymus Neoplasms diagnosis
Contrast Media
Lymphoma diagnostic imaging
Magnetic Resonance Imaging methods
Thymoma diagnostic imaging
Thymus Neoplasms diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1365-229X
- Volume :
- 75
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Clinical radiology
- Publication Type :
- Academic Journal
- Accession number :
- 32197918
- Full Text :
- https://doi.org/10.1016/j.crad.2020.02.010