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Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast.
- Source :
-
Translational medicine of aging [Transl Med Aging] 2019; Vol. 3, pp. 104-108. Date of Electronic Publication: 2019 Oct 31. - Publication Year :
- 2019
-
Abstract
- An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicative lifespan. Upon careful analysis of multiple independently derived haploid and homozygous diploid whi5Δ mutants, we find no effect on lifespan, but we do confirm the reduction in cell size. We suggest that instead of antagonizing lifespan, the elongated G1 phase of the cell cycle during aging may actually play an important role in allowing aged cells time to repair accumulating DNA damage.
Details
- Language :
- English
- ISSN :
- 2468-5011
- Volume :
- 3
- Database :
- MEDLINE
- Journal :
- Translational medicine of aging
- Publication Type :
- Academic Journal
- Accession number :
- 32190787
- Full Text :
- https://doi.org/10.1016/j.tma.2019.10.002