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Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma.
- Source :
-
Cancer cell [Cancer Cell] 2020 Mar 16; Vol. 37 (3), pp. 403-419.e6. - Publication Year :
- 2020
-
Abstract
- Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes of NKTCL based on genomic structural alterations and EBV sequences, we performed multi-omics study on 128 biopsy samples of newly diagnosed NKTCL and defined three prominent subtypes, which differ significantly in cell of origin, EBV gene expression, transcriptional signatures, and responses to asparaginase-based regimens and targeted therapy. Our findings thus identify molecular networks of EBV-associated pathogenesis and suggest potential clinical strategies on NKTCL.<br />Competing Interests: Declaration of Interests The authors declare no competing financial interests.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Gene Dosage
Gene Expression Regulation, Neoplastic
Genomics
Humans
Lymphoma, T-Cell mortality
Lymphoma, T-Cell pathology
Lymphoma, T-Cell virology
Molecular Targeted Therapy
Mutation
Natural Killer T-Cells pathology
Phylogeny
Transcriptome
Whole Genome Sequencing
Xenograft Model Antitumor Assays
Zebrafish
Herpesvirus 4, Human genetics
Lymphoma, T-Cell genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 37
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 32183952
- Full Text :
- https://doi.org/10.1016/j.ccell.2020.02.005