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Trapped Neutrophil Syndrome in a Border Collie.
- Source :
-
Journal of the American Animal Hospital Association [J Am Anim Hosp Assoc] 2020 May/Jun; Vol. 56 (3), pp. e56304. Date of Electronic Publication: 2020 Mar 17. - Publication Year :
- 2020
-
Abstract
- A 10 wk old female border collie was presented for hemorrhagic diarrhea and pelvic limb lameness. Examination revealed pain and effusion in multiple appendicular joints and pyrexia. Clinicopathologic testing revealed moderate neutropenia as well as nondegenerate neutrophilic inflammation in multiple joints. Radiographs showed capsular joint swelling and heterogeneous metaphyseal lucencies in the distal radius, ulna, femur, and tibia. Genetic testing confirmed a mutation in the vacuolar protein sorting-associated protein 13B gene and a diagnosis of trapped neutrophil syndrome (TNS). Within 24 hr of initiating prednisone therapy (1 mg/kg, per os , q 12 hr), the dog was afebrile and nonpainful with normal ambulation. Lameness recurred twice over the next 5 mo. At 9 mo of age, diagnostics showed severe erosive polyarthritis of both stifles with an inflammatory leukogram and arthrocentesis findings consistent with septic arthritis, and the dog died despite antibiotic therapy. This is the first case of TNS described in the North American literature, and it is unique in that we had the opportunity to document progression of radiographic abnormalities over more than 6 mo. TNS should be considered in young border collies with signs suggestive of immune-mediated polyarthritis, septic arthritis, or hypertrophic osteodystrophy, combined with neutropenia or gastrointestinal signs.
- Subjects :
- Animals
Arthritis complications
Arthritis diagnosis
Arthritis genetics
Diagnosis, Differential
Dog Diseases diagnostic imaging
Dogs
Female
Lameness, Animal etiology
Neutropenia complications
Neutropenia diagnosis
Neutropenia genetics
Pedigree
Vesicular Transport Proteins genetics
Arthritis veterinary
Dog Diseases diagnosis
Neutropenia veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1547-3317
- Volume :
- 56
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of the American Animal Hospital Association
- Publication Type :
- Academic Journal
- Accession number :
- 32182118
- Full Text :
- https://doi.org/10.5326/JAAHA-MS-6981