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Synthesis and herbicidal activities of aryloxyacetic acid derivatives as HPPD inhibitors.
- Source :
-
Beilstein journal of organic chemistry [Beilstein J Org Chem] 2020 Feb 19; Vol. 16, pp. 233-247. Date of Electronic Publication: 2020 Feb 19 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- A series of aryloxyacetic acid derivatives were designed and synthesized as 4-hydoxyphenylpyruvate dioxygenase (HPPD) inhibitors. Preliminary bioassay results reveal that these derivatives are promising Arabidopsis thaliana HPPD ( At HPPD) inhibitors, in particular compounds I12 ( K <subscript>i</subscript> = 0.011 µM) and I23 ( K <subscript>i</subscript> = 0.012 µM), which exhibit similar activities to that of mesotrione, a commercial HPPD herbicide ( K <subscript>i</subscript> = 0.013 µM). Furthermore, the newly synthesized compounds show significant greenhouse herbicidal activities against tested weeds at dosages of 150 g ai/ha. In particular, II4 exhibited high herbicidal activity for pre-emergence treatment that was slightly better than that of mesotrione. In addition, compound II4 was safe for weed control in maize fields at a rate of 150 g ai/ha, and was identified as the most potent candidate for a novel HPPD inhibitor herbicide. The compounds described herein may provide useful guidance for the design of new HPPD inhibiting herbicides and their modification.<br /> (Copyright © 2020, Wang et al.; licensee Beilstein-Institut.)
Details
- Language :
- English
- ISSN :
- 1860-5397
- Volume :
- 16
- Database :
- MEDLINE
- Journal :
- Beilstein journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32180842
- Full Text :
- https://doi.org/10.3762/bjoc.16.25