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Effect of Drug Pressure on Promoting the Emergence of Antimalarial-Resistant Parasites among Pregnant Women in Ghana.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 May 21; Vol. 64 (6). Date of Electronic Publication: 2020 May 21 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- The continuous spread of antimalarial drug resistance is a threat to current chemotherapy efficacy. Therefore, characterizing the genetic diversity of drug resistance markers is needed to follow treatment effectiveness and further update control strategies. Here, we genotyped Plasmodium falciparum resistance gene markers associated with sulfadoxine-pyrimethamine (SP) and artemisinin-based combination therapy (ACT) in isolates from pregnant women in Ghana. The prevalence of the septuple IRN I- A/FG K GS/T pfdhfr / pfdhps haplotypes, including the pfdhps A581G and A613S/T mutations, was high at delivery among post-SP treatment isolates (18.2%) compared to those of first antenatal care (before initiation of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine [IPTp-SP]; 6.1%; P = 0.03). Regarding the pfk13 marker gene, two nonsynonymous mutations (N458D and A481C) were detected at positions previously related to artemisinin resistance in isolates from Southeast Asia. These mutations were predicted in silico to alter the stability of the pfk13 propeller-encoding domain. Overall, these findings highlight the need for intensified monitoring and surveillance of additional mutations associated with increased SP resistance as well as emergence of resistance against artemisinin derivatives.<br /> (Copyright © 2020 American Society for Microbiology.)
- Subjects :
- Animals
Drug Combinations
Drug Resistance genetics
Female
Ghana
Humans
Plasmodium falciparum genetics
Pregnancy
Pregnant Women
Protozoan Proteins therapeutic use
Pyrimethamine pharmacology
Pyrimethamine therapeutic use
Sulfadoxine pharmacology
Sulfadoxine therapeutic use
Tetrahydrofolate Dehydrogenase genetics
Antimalarials pharmacology
Antimalarials therapeutic use
Malaria, Falciparum drug therapy
Parasites
Pharmaceutical Preparations
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 64
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 32179528
- Full Text :
- https://doi.org/10.1128/AAC.02029-19