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Neutrophil Extracellular Trap-Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Apr 15; Vol. 204 (8), pp. 2285-2294. Date of Electronic Publication: 2020 Mar 13. - Publication Year :
- 2020
-
Abstract
- Neutrophils promote tumor growth and metastasis at multiple stages of cancer progression. One mechanism through which this occurs is via release of neutrophil extracellular traps (NETs). We have previously shown that NETs trap tumor cells in both the liver and the lung, increasing their adhesion and metastasis following postoperative complications. Multiple studies have since shown that NETs play a role in tumor progression and metastasis. NETs are composed of nuclear DNA-derived web-like structures decorated with neutrophil-derived proteins. However, it is unknown which, if any, of these NET-affiliated proteins is responsible for inducing the metastatic phenotype. In this study, we identify the NET-associated carcinoembryonic Ag cell adhesion molecule 1 (CEACAM1) as an essential element for this interaction. Indeed, blocking CEACAM1 on NETs, or knocking it out in a murine model, leads to a significant decrease in colon carcinoma cell adhesion, migration and metastasis. Thus, this work identifies NET-associated CEACAM1 as a putative therapeutic target to prevent the metastatic progression of colon carcinoma.<br /> (Copyright © 2020 by The American Association of Immunologists, Inc.)
- Subjects :
- A549 Cells
Animals
Cell Line, Tumor
Colonic Neoplasms immunology
HT29 Cells
Humans
Mice
Neutrophils pathology
Antigens, CD metabolism
Carcinoembryonic Antigen metabolism
Cell Adhesion Molecules metabolism
Colonic Neoplasms metabolism
Colonic Neoplasms pathology
Extracellular Traps immunology
Extracellular Traps metabolism
Neutrophils immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 204
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 32169849
- Full Text :
- https://doi.org/10.4049/jimmunol.1900240