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Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum .
- Source :
-
Natural product research [Nat Prod Res] 2021 Nov; Vol. 35 (22), pp. 4534-4541. Date of Electronic Publication: 2020 Mar 12. - Publication Year :
- 2021
-
Abstract
- Descaudatine A ( 1 ), an undescribed phenolic glycoside, along with a known analogue ( 2 ) and ten flavonoids ( 3-12 ), were isolated from the whole plant of Desmodium caudatum . Compounds 1 and 4 exhibited potent antioxidant activities with the IC <subscript>50</subscript> of 58.59 μM and 31.31 μM, respectively, which were approached to that of the positive control Vitamin C (IC <subscript>50</subscript> = 46.32 μM). Meanwhile, 12 showed moderate antioxidant activity with the IC <subscript>50</subscript> of 173.9 μM. Besides, compounds 3 and 6 inhibited the proliferation of HeLa cells with IC <subscript>50</subscript> values of 56.14 μM and 69.04 μM, respectively. Further studies indicated that 3 and 6 could dose-dependently induce PARP cleavage and might trigger caspase-3, 8, 9 activation to induce apoptosis. RXRα is an ideal anticancer target of nuclear receptor. The reporter gene assay of RXRα indicated that 3 and 6 could inhibited the 9- cis -RA induced RXRα transcription in a concentration-dependent manner.
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 35
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 32162979
- Full Text :
- https://doi.org/10.1080/14786419.2020.1739044