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The epidemiology and clinical features of selective immunoglobulin M deficiency: A single-center study in China.
- Source :
-
Journal of clinical laboratory analysis [J Clin Lab Anal] 2020 Jul; Vol. 34 (7), pp. e23289. Date of Electronic Publication: 2020 Mar 10. - Publication Year :
- 2020
-
Abstract
- Background: Selective immunoglobulin M deficiency (SIgMD) is a rare primary immunodeficiency that is frequently reported in Western countries. However, large epidemiological and clinical studies of SIgMD in China are still lacking. Herein, we describe a cohort of SIgMD subjects in a large tertiary university hospital in China.<br />Methods: A cross-sectional study included 139 668 participants at First Affiliated Hospital of Wenzhou Medical University from January 2014 to October 2018 was conducted. Individuals with a serum IgM level less than 0.3 g/L with normal levels of serum IgA and IgG were defined as having SIgMD.<br />Result: A total of 63 subjects met the criteria for SIgMD(63/139668, 0.045%), with a male-to-female ratio of 0.85, aged from 19 to 99 years. The most common clinical manifestation was autoimmune disorders (38/63, 60.32%), while the second most common manifestation was infections (21/63, 33.33%). Neither allergies nor tumors were found among these 63 SIgMD subjects. Most importantly, there were 30 patients with systemic lupus erythematosus among these 63 SIgMD subjects, accounting for 47.62% of all SIgMD subjects.<br />Conclusion: To our knowledge, we describe here the first large single-center cohort of adult patients affected by SIgMD in China. The most common clinical manifestation was autoimmune disorders, specifically systemic lupus erythematosus.<br /> (© 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
China epidemiology
Cross-Sectional Studies
Female
Humans
Immunoglobulin M blood
Infections epidemiology
Infections immunology
Lupus Erythematosus, Systemic blood
Lupus Erythematosus, Systemic epidemiology
Lupus Erythematosus, Systemic immunology
Male
Middle Aged
Young Adult
Immunoglobulin M deficiency
Immunologic Deficiency Syndromes epidemiology
Immunologic Deficiency Syndromes etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-2825
- Volume :
- 34
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of clinical laboratory analysis
- Publication Type :
- Academic Journal
- Accession number :
- 32157736
- Full Text :
- https://doi.org/10.1002/jcla.23289