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AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2020 Apr 01; Vol. 142 (13), pp. 5985-5990. Date of Electronic Publication: 2020 Mar 20. - Publication Year :
- 2020
-
Abstract
- We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
- Subjects :
- Alkynes chemical synthesis
Alkynes chemistry
Azides chemical synthesis
Azides chemistry
Click Chemistry
Cycloaddition Reaction
DNA chemistry
Macrocyclic Compounds chemical synthesis
Macrocyclic Compounds chemistry
Oligonucleotides chemistry
Rotaxanes chemistry
Copper chemistry
DNA chemical synthesis
Oligonucleotides chemical synthesis
Rotaxanes chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 142
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 32155338
- Full Text :
- https://doi.org/10.1021/jacs.0c01670