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[The study of the innate and acquired cellular immunity chains indicators in the peripheral blood of patients with HIV infection.]

Authors :
Serebrovskaya LV
Ivanova LA
Selimova LM
Kalnina LB
Nosik DN
Source :
Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2020; Vol. 65 (1), pp. 24-28.
Publication Year :
2020

Abstract

In this study was made an attempt to reveal additional laboratory markers of white blood for preliminary estimation level of HIV-infection development. Essentially such markers these are in progress without complex equipment and expensive reagent. It was studied alterations of basic values cells of innate and acquired immunity of peripheral blood HIV-infected individuals with and without antiretroviral treatment (ART) during infection. It was estimate value leukocytes, neutrophils, monocytes, lymhpocytes, T-lymhpocytes, CD <subscript>4</subscript> <superscript>+</superscript> , CD <subscript>8</subscript> <superscript>+</superscript> T-cells, CD <subscript>4</subscript> /CD <subscript>8</subscript> index. It was used the first analysis in the time of registration for regular medical check-up and the intermediate derived during 2017-2018 years. Patients without ART and with ART before and after treatment had rates of leukocytes, lymhpocytes, T-lymhpocytes, monocytes and neutrophils within the normal guideline. Essential changes were observed in basic conventional laboratory parameters evaluation of HIV-infection dynamic (parameters of CD <subscript>4</subscript> <superscript>+</superscript> , CD <subscript>8</subscript> <superscript>+</superscript> T-cells, CD <subscript>4</subscript> /CD <subscript>8</subscript> index). Thereby it was impossible to reveal supplementary immunological markers of HIVinfection.<br />Competing Interests: The authors declare no conflict of interest.

Details

Language :
Russian
ISSN :
0869-2084
Volume :
65
Issue :
1
Database :
MEDLINE
Journal :
Klinicheskaia laboratornaia diagnostika
Publication Type :
Academic Journal
Accession number :
32155003
Full Text :
https://doi.org/10.18821/0869-2084-2020-65-1-24-28