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The detection, pharmacokinetics and behavioral effects of diisopropylamine dichloroacetate (DADA) in the horse: a preliminary report.
- Source :
-
General pharmacology [Gen Pharmacol] 1988; Vol. 19 (5), pp. 683-8. - Publication Year :
- 1988
-
Abstract
- 1. Drug administration studies using diisopropylamine dichloroacetate (DADA) and diisopropylamine (DIPA) were conducted in Thoroughbred and Standardbred horses to assess physiological effects and develop detection methods. 2. Four horses received 0.08 mg DADA/kg body wt and showed no changes in heart and respiratory rates or body temperature as measured over a 1-hr period after administration. A transient diuretic effect was found to occur in 2 mares dosed with 0.80 mg DADA/kg body wt. 3. A qualitative detection method using thin-layer chromatography was developed to detect DIPA, the major metabolite of DADA in equine urine. A quantitative detection method (lower limit of detection 0.5 micrograms/ml urine) for this metabolite was also developed using gas chromatography. 4. Neither DADA or the free base, DIPA, were detectable in equine blood samples using the above-mentioned methodologies.
- Subjects :
- Animals
Antihypertensive Agents blood
Antihypertensive Agents urine
Chromatography, Gas
Chromatography, Thin Layer
Female
Horses physiology
Male
Mass Spectrometry
Quaternary Ammonium Compounds blood
Quaternary Ammonium Compounds urine
Respiration drug effects
Antihypertensive Agents pharmacology
Behavior, Animal drug effects
Horses metabolism
Quaternary Ammonium Compounds pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0306-3623
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- General pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 3215480
- Full Text :
- https://doi.org/10.1016/0306-3623(88)90129-2