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Amplified Photoacoustic Signal and Enhanced Photothermal Conversion of Polydopamine-Coated Gold Nanobipyramids for Phototheranostics and Synergistic Chemotherapy.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Apr 01; Vol. 12 (13), pp. 14866-14875. Date of Electronic Publication: 2020 Mar 19. - Publication Year :
- 2020
-
Abstract
- Light-responsive nanoprobes were suffering from the threat of high-dose laser irradiation, and it was important for constructing new nanoprobes for safe and efficient phototheranostics. Here, polydopamine (PDA)-coated gold nanobipyramids (AuNBPs@PDA) were synthesized for amplified photoacoustic (PA) signal and enhanced photothermal conversion with low-dose laser irradiation and then doxorubicin (DOX)-loaded AuNBPs@PDA-DOX nanoprobes were constructed for PA imaging-guided synergistic photothermal therapy (PTT) and chemotherapy. The AuNBPs@PDA nanoparticles possessed higher photothermal conversion efficiency (42.07%) and stronger PA signal than those of AuNBP nanoparticles, and the AuNBPs@PDA-DOX nanoprobes showed dual-responsive DOX release of pH and photothermal stimulation. With low-dose laser irradiation (1.0 W/cm <superscript>2</superscript> ) and low-concentration AuNBPs@PDA-DOX (60 μg/mL), the 4T1 cell viability was reduced to about 5%, owing to the combination of PTT and chemotherapy, compared with 42.3% of single chemotherapy and 25.3% of single PTT. Moreover, by modeling 4T1 tumor-bearing nude mice, in vivo PA imaging was achieved and the tumors were completely inhibited, demonstrating the excellent synergistic effect of PTT/chemotherapy. Therefore, the developed AuNBPs@PDA-DOX nanoprobes can be used for phototheranostics and synergistic chemotherapy, achieving low-dose laser irradiation and high-efficient visualized theranostics.
- Subjects :
- Animals
Antibiotics, Antineoplastic pharmacology
Antibiotics, Antineoplastic therapeutic use
Body Weight drug effects
Body Weight radiation effects
Cell Line, Tumor
Cell Survival drug effects
Doxorubicin chemistry
Doxorubicin pharmacology
Doxorubicin therapeutic use
Drug Carriers chemistry
Drug Carriers toxicity
Drug Liberation
Female
Humans
Lasers
Mice
Mice, Nude
Neoplasms drug therapy
Neoplasms pathology
Photoacoustic Techniques
Phototherapy
Xenograft Model Antitumor Assays
Antibiotics, Antineoplastic chemistry
Gold chemistry
Indoles chemistry
Nanostructures chemistry
Neoplasms therapy
Polymers chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 12
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 32153178
- Full Text :
- https://doi.org/10.1021/acsami.9b22979