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Effect of Transplantation of Neural Stem and Progenitor Cells on Memory in Animals with Alzheimer's Type Neurodegeneration.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 Feb; Vol. 168 (4), pp. 589-596. Date of Electronic Publication: 2020 Mar 09. - Publication Year :
- 2020
-
Abstract
- The effects of systemic and intracerebral transplantation of human fetal neural stem and progenitor cells were studied on the model of olfactory bulbectomy in mice with developing signs of sporadic Alzheimer's disease. It was found that transplantation of these cells at certain stages of disease development contributed to improvement of spatial memory and preservation of hippocampal neurons in these animals.
- Subjects :
- Administration, Intravenous
Alzheimer Disease pathology
Alzheimer Disease physiopathology
Animals
Cell Differentiation
Disease Models, Animal
Fetal Stem Cells cytology
Fetal Stem Cells physiology
Fetus
Hippocampus pathology
Hippocampus physiopathology
Humans
Injections, Intralesional
Maze Learning physiology
Mice
Mice, Inbred Strains
Neural Stem Cells cytology
Neural Stem Cells physiology
Neurogenesis physiology
Neurons cytology
Neurons physiology
Olfactory Bulb surgery
Primary Cell Culture
Spheroids, Cellular cytology
Spheroids, Cellular physiology
Transplantation, Heterologous
Alzheimer Disease therapy
Fetal Stem Cells transplantation
Neural Stem Cells transplantation
Spatial Memory physiology
Spheroids, Cellular transplantation
Stem Cell Transplantation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 168
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32152851
- Full Text :
- https://doi.org/10.1007/s10517-020-04758-0