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Cytochemical Evaluation of the Toxic Effects of Combined Antituberculosis Substances on Metabolic State of Blood Lymphocytes.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 Feb; Vol. 168 (4), pp. 470-473. Date of Electronic Publication: 2020 Mar 07. - Publication Year :
- 2020
-
Abstract
- Combined antituberculosis substances induced a dose-dependent changes in activity of dehydrogenases and hydrolases in rat lymphocytes. The main toxic effect of the substances was related to inhibition of mitochondrial dehydrogenases (succinate dehydrogenase and α-glycerol phosphate dehydrogenase) usually followed by suppression of activity of hydrolytic enzymes (acid phosphatase and non-specific esterase). Opposite changes in lactate dehydrogenase activity reflected specific features of intoxication.
- Subjects :
- Acid Phosphatase genetics
Acid Phosphatase metabolism
Administration, Oral
Animals
Animals, Outbred Strains
Drug Combinations
Esterases genetics
Esterases metabolism
Gene Expression drug effects
Glycerolphosphate Dehydrogenase antagonists & inhibitors
Glycerolphosphate Dehydrogenase genetics
Glycerolphosphate Dehydrogenase metabolism
L-Lactate Dehydrogenase genetics
L-Lactate Dehydrogenase metabolism
Lymphocytes cytology
Lymphocytes enzymology
Male
Primary Cell Culture
Rats
Succinate Dehydrogenase antagonists & inhibitors
Succinate Dehydrogenase genetics
Succinate Dehydrogenase metabolism
Antitubercular Agents toxicity
Ethambutol toxicity
Fluoroquinolones toxicity
Isoniazid toxicity
Lymphocytes drug effects
Prothionamide toxicity
Pyrazinamide toxicity
Rifampin toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 168
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32146623
- Full Text :
- https://doi.org/10.1007/s10517-020-04733-9