Exposure to lead increases the risk of meningioma and brain cancer: A meta-analysis.

Authors :: Meng Y
Tang C
Yu J
Meng S
Zhang W
Source :: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2020 Jul; Vol. 60, pp. 126474. Date of Electronic Publication: 2020 Feb 27.
Publication Year :: 2020
Abstract: Objective: To analyze the relationship between environmental lead exposure and various types of brain tumors. Methods: Search databases PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure (CNKI) as of July 1, 2019. Stata 15.0 software was used for analysis. Results: In the case control, lead exposure was associated with gliomas and meningiomas 0.82 (95 % CI: 0.69, 0.95) and 1.06 (95 % CI: 0.65, 1.46). In the cohort study, lead exposure was associated with brain cancer and meningiomas 1.07 (95 % CI: 0.95, 1.19) and 1.06 (95 % CI: 0.94, 1.17). The risk of childhood brain tumors associated with parental lead exposure was 1.17 (95 % CI: 0.99, 1.34). Conclusions: Lead may be a risk factor for meningiomas and brain cancers. However, the glioma results suggest that lead may be a protective factor, which needs to be further studied. Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest. (Copyright © 2020 Elsevier GmbH. All rights reserved.)

Subjects :: Animals
Cohort Studies
Humans
Risk Factors
Brain Neoplasms chemically induced
Environmental Exposure adverse effects
Lead adverse effects
Meningioma chemically induced

Language :: English
ISSN :: 1878-3252
Volume :: 60
Database :: MEDLINE
Journal :: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Publication Type :: Academic Journal
Accession number :: 32146339
Full Text :: https://doi.org/10.1016/j.jtemb.2020.126474

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