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Sulfated and Oxygenated Imidazoline Derivatives: Synthesis, Antioxidant Activity and Light-Mediated Antibacterial Activity.
- Source :
-
ChemMedChem [ChemMedChem] 2020 May 19; Vol. 15 (10), pp. 851-861. Date of Electronic Publication: 2020 Apr 02. - Publication Year :
- 2020
-
Abstract
- Imidazoline derivatives with different exocyclic substituents were simply prepared from common starting materials. The procedures were carried out in an eco-friendly manner. The antioxidant activity of these derivatives was explored by different experimental assays, such as ABTS <superscript>.+</superscript> and DPPH <superscript>.</superscript> scavenging assay, as well as reducing power assay. The structural differences are discussed in terms of the results. Sulfur analogs showed higher antioxidant activity than their oxygenated counterparts. The same tendency was observed in microbiological studies, in which the same imidazoline compounds were assayed for light-mediated activity against of Staphylococcus aureus and Escherichia coli strains. A light-enhanced activity was observed for almost all the sulfated imidazolines after exposure to UV-A (400-320 nm) light.<br /> (© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Antioxidants chemical synthesis
Antioxidants chemistry
Benzothiazoles antagonists & inhibitors
Biphenyl Compounds antagonists & inhibitors
Dose-Response Relationship, Drug
Imidazolines chemical synthesis
Imidazolines chemistry
Microbial Sensitivity Tests
Molecular Structure
Picrates antagonists & inhibitors
Structure-Activity Relationship
Sulfonic Acids antagonists & inhibitors
Anti-Bacterial Agents pharmacology
Antioxidants pharmacology
Escherichia coli drug effects
Imidazolines pharmacology
Light
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1860-7187
- Volume :
- 15
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- ChemMedChem
- Publication Type :
- Academic Journal
- Accession number :
- 32144846
- Full Text :
- https://doi.org/10.1002/cmdc.202000048