MACULAR HOLE CLOSURE WITH TOPICAL STEROIDS.

Authors :: Bonnell AC
Prenner S
Weinstein MS
Fine HF
Source :: Retinal cases & brief reports [Retin Cases Brief Rep] 2022 May 01; Vol. 16 (3), pp. 351-354. Date of Electronic Publication: 2020 Mar 02.
Publication Year :: 2022
Abstract: Background and Objective: To report the outcomes of topical difluprednate 0.05% use in the closure of full-thickness macular holes.<br />Patients and Methods: Retrospective chart review of 4 patients with full-thickness macular holes who received difluprednate drops 4 times daily for a minimum of 12 weeks. Main outcome measures were macular hole status assessed with optical coherence tomography, visual acuity, intraocular pressure, and complications of treatment.<br />Results: All patients had macular hole closure within 12 weeks of difluprednate exposure. Mean time to macular hole closure was 5 weeks (range, 2-12 weeks). Visual acuity improved with macular hole closure. Average baseline visual acuity was 20/42. Average visual acuity after macular hole closure was 20/26 (P = 0.14). Two patients experienced increased intraocular pressure with topical steroid use.<br />Conclusion: Exposure to difluprednate in this cohort of patients with full-thickness macular holes was associated with reduced macular edema, macular hole closure, and visual improvement.