Importation of Extensively Drug-Resistant Salmonella enterica Serovar Typhi Cases in Ontario, Canada.

Authors :: Eshaghi A
Zittermann S
Bharat A
Mulvey MR
Allen VG
Patel SN
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Apr 21; Vol. 64 (5). Date of Electronic Publication: 2020 Apr 21 (Print Publication: 2020).
Publication Year :: 2020
Abstract: A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections ( n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were genetically related to the Pakistan outbreak strain. The appearance of XDR typhoid cases in Ontario prompted a provincial wide alert to physicians to recommend treatment with carbapenems or azithromycin in suspected typhoid cases with travel history to Pakistan.<br /> (© Crown copyright 2020.)

Subjects :: Anti-Bacterial Agents therapeutic use
Azithromycin therapeutic use
Carbapenems therapeutic use
Humans
Microbial Sensitivity Tests
Ontario epidemiology
Pakistan
Salmonella enterica genetics
Travel
Typhoid Fever drug therapy
Whole Genome Sequencing
Drug Resistance, Multiple, Bacterial
Salmonella enterica drug effects
Typhoid Fever epidemiology
Typhoid Fever microbiology

Full Text Access

Tools