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Coevolution of Resistance Against Antimicrobial Peptides.
- Source :
-
Microbial drug resistance (Larchmont, N.Y.) [Microb Drug Resist] 2020 Aug; Vol. 26 (8), pp. 880-899. Date of Electronic Publication: 2020 Mar 02. - Publication Year :
- 2020
-
Abstract
- Antimicrobial peptides (AMPs) are produced by all forms of life, ranging from eukaryotes to prokaryotes, and they are a crucial component of innate immunity, involved in clearing infection by inhibiting pathogen colonization. In the recent past, AMPs received high attention due to the increase of extensive antibiotic resistance by these pathogens. AMPs exhibit a diverse spectrum of activity against bacteria, fungi, parasites, and various types of cancer. AMPs are active against various bacterial pathogens that cause disease in animals and plants. However, because of the coevolution of host and pathogen interaction, bacteria have developed the mechanisms to sense and exhibit an adaptive response against AMPs. These resistance mechanisms are playing an important role in bacterial virulence within the host. Here, we have discussed the different resistance mechanisms used by gram-positive and gram-negative bacteria to sense and combat AMP actions. Understanding the mechanism of AMP resistance may provide directions toward the development of novel therapeutic strategies to control multidrug-resistant pathogens.
- Subjects :
- Biofilms drug effects
Cell Membrane metabolism
Cell Wall drug effects
Cell Wall metabolism
Drug Resistance, Multiple, Bacterial drug effects
Gram-Negative Bacteria drug effects
Gram-Positive Bacteria drug effects
Microbial Sensitivity Tests
Peptidoglycan metabolism
Anti-Bacterial Agents pharmacology
Drug Resistance, Multiple, Bacterial physiology
Gram-Negative Bacteria metabolism
Gram-Positive Bacteria metabolism
Pore Forming Cytotoxic Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1931-8448
- Volume :
- 26
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Microbial drug resistance (Larchmont, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 32119634
- Full Text :
- https://doi.org/10.1089/mdr.2019.0291