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Identification of markers of depression and neurotoxicity in pesticide exposed agriculture workers.
- Source :
-
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2020 Jun; Vol. 34 (6), pp. e22477. Date of Electronic Publication: 2020 Mar 01. - Publication Year :
- 2020
-
Abstract
- Earlier, we reported that chronic exposure to pesticides causes a reduction in the acetylcholinesterase activity and hematological and biochemical alterations in agriculture workers. In continuation with that, the present study aimed to investigate the pesticide-induced neurochemical imbalance and its association with behavior alterations in agricultural workers. A significant increase in depressive symptoms, assessed by the Beck Depression Inventory-II was observed in pesticide exposed workers as compared to the unexposed. A decrease in the level of dopamine in plasma and levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acids, norepinephrine, serotonin, and hydroxyindoleacetic acid in urine was also observed. An increase in the levels of MAO-A and MAO-B has also been observed in these individuals. The decreased levels of neurotransmitters in the blood and urine have been linked with increased levels of MAO and pesticide residues in plasma and urine. Furthermore, these changes were associated with a higher incidence of depression in agricultural workers.<br /> (© 2020 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Adult
Aged
Biomarkers blood
Biomarkers urine
Depression blood
Depression epidemiology
Depression urine
Dopamine blood
Dopamine urine
Female
Humans
Incidence
India epidemiology
Male
Middle Aged
Monoamine Oxidase blood
Monoamine Oxidase urine
Neurotoxicity Syndromes blood
Neurotoxicity Syndromes epidemiology
Neurotoxicity Syndromes urine
Neurotransmitter Agents blood
Neurotransmitter Agents urine
Pesticide Residues blood
Pesticide Residues urine
Young Adult
Depression chemically induced
Farmers
Neurotoxicity Syndromes etiology
Occupational Exposure
Pesticide Residues toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1099-0461
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of biochemical and molecular toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 32115844
- Full Text :
- https://doi.org/10.1002/jbt.22477