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Prognostic scoring system for metastatic spine tumors derived from hepatocellular carcinoma.
- Source :
-
Journal of orthopaedic surgery (Hong Kong) [J Orthop Surg (Hong Kong)] 2020 Jan-Apr; Vol. 28 (1), pp. 2309499019899167. - Publication Year :
- 2020
-
Abstract
- Purpose: The prognosis of hepatocellular carcinoma (HCC) has recently improved, and so clinicians have greater opportunity to treat HCC-derived spinal metastases. Therefore, predicting life expectancy is important for determining the optimal treatment strategy for such tumors. This study aimed to investigate the prognostic factors for HCC-derived metastatic spine tumors and to develop a scoring system for predicting life expectancy in such cases.<br />Methods: The posttreatment survival time and factors that might influence it were investigated in 62 patients with HCC-derived metastatic spine tumors who were treated at our department (surgery: 27 patients and conservative treatment: 35 patients), and a prognostic scoring system for predicting life expectancy was developed by combining the factors that significantly influenced survival.<br />Results: In the univariate analyses, sex, the patient's general condition, the presence/absence of major internal organ metastasis, the total revised Tokuhashi score, the serum albumin level, Child-Pugh class, spinal surgery, and bone-modifying agent (BMA) treatment were found to influence the posttreatment survival time. These factors were subjected to multivariate analysis, and a novel scoring system for predicting life expectancy based on the patient's general condition, the serum albumin level (or Child-Pugh class), and BMA treatment was developed. In the retrospective analysis, the concordance rate between the patients' life expectancy and actual survival times was 90.3%.<br />Conclusion: The patient's general condition, the serum albumin level (or Child-Pugh class), and BMA treatment influenced the posttreatment survival times of patients with HCC-derived metastatic spine tumors. A prognostic scoring system based on these factors was proposed.
- Subjects :
- Aged
Carcinoma, Hepatocellular diagnosis
Carcinoma, Hepatocellular mortality
Female
Humans
Japan epidemiology
Life Expectancy
Liver Neoplasms mortality
Male
Neoplasm Metastasis
Prognosis
Retrospective Studies
Spinal Neoplasms diagnosis
Spinal Neoplasms mortality
Survival Rate trends
Carcinoma, Hepatocellular secondary
Liver Neoplasms pathology
Spinal Neoplasms secondary
Subjects
Details
- Language :
- English
- ISSN :
- 2309-4990
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic surgery (Hong Kong)
- Publication Type :
- Academic Journal
- Accession number :
- 32114893
- Full Text :
- https://doi.org/10.1177/2309499019899167