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Nanotechnology approaches in the current therapy of skin cancer.
- Source :
-
Advanced drug delivery reviews [Adv Drug Deliv Rev] 2020 Jan 01; Vol. 153, pp. 109-136. Date of Electronic Publication: 2020 Feb 27. - Publication Year :
- 2020
-
Abstract
- Skin cancer is a high burden disease with a high impact on global health. Conventional therapies have several drawbacks; thus, the development of effective therapies is required. In this context, nanotechnology approaches are an attractive strategy for cancer therapy because they enable the efficient delivery of drugs and other bioactive molecules to target tissues with low toxic effects. In this review, nanotechnological tools for skin cancer will be summarized and discussed. First, pathology and conventional therapies will be presented, followed by the challenges of skin cancer therapy. Then, the main features of developing efficient nanosystems will be discussed, and next, the most commonly used nanoparticles (NPs) described in the literature for skin cancer therapy will be presented. Subsequently, the use of NPs to deliver chemotherapeutics, immune and vaccine molecules and nucleic acids will be reviewed and discussed as will the combination of physical methods and NPs. Finally, multifunctional delivery systems to codeliver anticancer therapeutic agents containing or not surface functionalization will be summarized.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Cutaneous
Antineoplastic Agents administration & dosage
Antineoplastic Agents pharmacology
Dacarbazine pharmacology
Dacarbazine therapeutic use
Drug Carriers administration & dosage
Drug Carriers chemistry
Drug Resistance, Neoplasm physiology
Fluorouracil pharmacology
Fluorouracil therapeutic use
Gold chemistry
Humans
Melanoma drug therapy
Melanoma pathology
Metal Nanoparticles administration & dosage
Metal Nanoparticles chemistry
Nanoparticles administration & dosage
Nanoparticles chemistry
Nanotechnology
Particle Size
Skin Absorption physiology
Skin Physiological Phenomena
Surface Properties
Antineoplastic Agents therapeutic use
Drug Carriers metabolism
Nanoparticles metabolism
Skin Neoplasms drug therapy
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8294
- Volume :
- 153
- Database :
- MEDLINE
- Journal :
- Advanced drug delivery reviews
- Publication Type :
- Academic Journal
- Accession number :
- 32113956
- Full Text :
- https://doi.org/10.1016/j.addr.2020.02.005