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Assessment of biopsy proven liver fibrosis by two-dimensional shear wave elastography in patients with primary biliary cholangitis.
- Source :
-
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2020 May; Vol. 52 (5), pp. 555-560. Date of Electronic Publication: 2020 Feb 26. - Publication Year :
- 2020
-
Abstract
- Background: Two-dimensional shear-wave elastography (2D-SWE) is an ultrasound-based technique used to stage liver fibrosis by measuring liver stiffness (LS). The diagnostic performance of 2D-SWE for assessing liver fibrosis in patients with primary biliary cholangitis (PBC) has not been reported before.<br />Aims: To investigate the diagnostic performance of 2D-SWE for staging liver fibrosis in patients with PBC by using histologic analysis as a reference standard.<br />Methods: Patients with PBC who underwent liver biopsy and 2D-SWE were retrospectively collected. Liver fibrosis was staged according to the Scheuer scoring system. Areas under receiver operating characteristic curve (AUROC) was constructed to assess the accuracy of 2D-SWE and serum fibrosis models for staging liver fibrosis.<br />Results: The diagnostic performance characteristics were determined for 157 patients with PBC. The AUROCs of LS measured by 2D-SWE for significant fibrosis, severe fibrosis, and cirrhosis were 0.88, 0.97 and 0.99, respectively. The cutoff values of LS measured by 2D-SWE in discriminating significant fibrosis, severe fibrosis, and cirrhosis were 10.7 kPa, 12.2 kPa and 14.1 kPa, respectively. The diagnostic accuracy of 2D-SWE for staging liver fibrosis was 73.9%.<br />Conclusions: 2D-SWE is an efficient noninvasive method for the assessment of liver fibrosis in patients with PBC.<br /> (Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Area Under Curve
Biopsy
China
Cross-Sectional Studies
Data Accuracy
Female
Humans
Male
Middle Aged
Predictive Value of Tests
ROC Curve
Retrospective Studies
Elasticity Imaging Techniques methods
Liver diagnostic imaging
Liver pathology
Liver Cirrhosis, Biliary diagnostic imaging
Liver Cirrhosis, Biliary pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3562
- Volume :
- 52
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 32111390
- Full Text :
- https://doi.org/10.1016/j.dld.2020.02.002