Concomitant BRAF Mutation in Hairy Cell Leukemia and Papillary Thyroid Cancer: Case Report.

Authors :: Mohamed SF
Helmi F
El-Akiki S
El Omri H
Nashwan A
Yassin MA
Source :: Case reports in oncology [Case Rep Oncol] 2019 Dec 17; Vol. 12 (3), pp. 922-927. Date of Electronic Publication: 2019 Dec 17 (Print Publication: 2019).
Publication Year :: 2019
Abstract: Hairy cell leukemia (HCL) is rare type of leukemia. This neoplasm is well-known to present with pancytopenia and splenomegaly. HCL is associated with BRAF mutation in 100% of cases. It is also associated with hematological and oncological malignancies such as melanoma and papillary thyroid cancer. Although the association of both cancers (HCL and papillary thyroid cancer) with BRAF mutation is well established in the literature, as far as we know it has not been reported before in the same patient. Here we report 48-year-old male diagnosed with HCL and papillary thyroid cancer and who is BRAF positive in both diagnostic tissues.<br />Competing Interests: The authors have no conflicts to declare.<br /> (Copyright © 2019 by S. Karger AG, Basel.)

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