3D hollow-out TiO 2 nanowire cluster/GOx as an ultrasensitive photoelectrochemical glucose biosensor.

Ultra-high sensitivity is difficult to achieve using conventional enzymatic glucose biosensors due to the lack of exposed active sites and steric-hinderance effects. Thus, in the present study, we report a photoelectrochemical (PEC) enzymatic glucose biosensor based on 3-dimensional (3D) hollow-out titanium dioxide (TiO ₂ ) nanowire cluster (NWc)/glucose oxidase (GOx), providing more number of exposed active sites, thus constructing a sensor with a higher affinity toward glucose reaction. Excellent performance with an ultra-high sensitivity of 58.9 μA mM ^-1 cm ^-2 and 0-2 mM linear range with a determination limit of 8.7 μM was obtained for the detection of glucose. This study might provide a new approach to expose active sites efficiently for remarkable photoelectrochemical performances.