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Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study.
- Source :
-
Scientific reports [Sci Rep] 2020 Feb 26; Vol. 10 (1), pp. 3452. Date of Electronic Publication: 2020 Feb 26. - Publication Year :
- 2020
-
Abstract
- Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AO <subscript>post-BD</subscript> ), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03-1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02-1.04)] and females [1.03 (1.02-1.05)]. The positive predictive value of AO for AO <subscript>post-BD</subscript> was 59.1% (52.0-66.2%) in men and 42.6% (35.1-50.1%) in women. AO <subscript>post-BD</subscript> incidence was 2.6 (1.7-3.4) male and 1.6 (1.0-2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AO <subscript>post-BD</subscript> incidence is expected to be half of AO incidence.
- Subjects :
- Adult
Asthma pathology
Bronchodilator Agents therapeutic use
Cohort Studies
Europe epidemiology
Female
Humans
Incidence
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive drug therapy
Pulmonary Disease, Chronic Obstructive epidemiology
Risk Factors
Sex Factors
Smoking
Spirometry
Pulmonary Disease, Chronic Obstructive pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32103063
- Full Text :
- https://doi.org/10.1038/s41598-020-60478-5