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Synthesis of novel 9 R/S -acyloxy derivatives of cinchonidine and cinchonine as insecticidal agents.
- Source :
-
Journal of Asian natural products research [J Asian Nat Prod Res] 2021 Feb; Vol. 23 (2), pp. 163-175. Date of Electronic Publication: 2020 Feb 24. - Publication Year :
- 2021
-
Abstract
- Endeavor to discover biorational natural products-based insecticides, two series (27) of novel 9 R/S -acyloxy derivatives of cinchonidine and cinchonine were prepared and assessed for their insecticidal activity against Mythimna separata in vivo by the leaf-dipping method at 1 mg/mL. Among all the compounds, especially derivatives 6l and 6o exhibited the best insecticidal activity with final mortality rates of 75.0% and 71.4%, respectively. Overall, a free 9-hydroxyl group is not a prerequisite for insecticidal activity and C9-substitution is well tolerated; the configuration of C8/9 position is important for insecticidal activity, and 9 S -configuration is optimal; 6'-OCH <subscript>3</subscript> moiety is not necessary, removal of it is also acceptable. [Formula: see text].
- Subjects :
- Animals
Cinchona Alkaloids
Larva
Molecular Structure
Insecticides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2213
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of Asian natural products research
- Publication Type :
- Academic Journal
- Accession number :
- 32091234
- Full Text :
- https://doi.org/10.1080/10286020.2020.1729136