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Alterations and test-retest reliability of functional connectivity network measures in cerebral small vessel disease.
- Source :
-
Human brain mapping [Hum Brain Mapp] 2020 Jul; Vol. 41 (10), pp. 2629-2641. Date of Electronic Publication: 2020 Feb 22. - Publication Year :
- 2020
-
Abstract
- While structural network analysis consolidated the hypothesis of cerebral small vessel disease (SVD) being a disconnection syndrome, little is known about functional changes on the level of brain networks. In patients with genetically defined SVD (CADASIL, n = 41) and sporadic SVD (n = 46), we independently tested the hypothesis that functional networks change with SVD burden and mediate the effect of disease burden on cognitive performance, in particular slowing of processing speed. We further determined test-retest reliability of functional network measures in sporadic SVD patients participating in a high-frequency (monthly) serial imaging study (RUN DMC-InTENse, median: 8 MRIs per participant). Functional networks for the whole brain and major subsystems (i.e., default mode network, DMN; fronto-parietal task control network, FPCN; visual network, VN; hand somatosensory-motor network, HSMN) were constructed based on resting-state multi-band functional MRI. In CADASIL, global efficiency (a graph metric capturing network integration) of the DMN was lower in patients with high disease burden (standardized beta = -.44; p [corrected] = .035) and mediated the negative effect of disease burden on processing speed (indirect path: std. beta = -.20, p = .047; direct path: std. beta = -.19, p = .25; total effect: std. beta = -.39, p = .02). The corresponding analyses in sporadic SVD showed no effect. Intraclass correlations in the high-frequency serial MRI dataset of the sporadic SVD patients revealed poor test-retest reliability and analysis of individual variability suggested an influence of age, but not disease burden, on global efficiency. In conclusion, our results suggest that changes in functional connectivity networks mediate the effect of SVD-related brain damage on cognitive deficits. However, limited reliability of functional network measures, possibly due to age-related comorbidities, impedes the analysis in elderly SVD patients.<br /> (© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
CADASIL diagnostic imaging
CADASIL pathology
CADASIL physiopathology
Connectome methods
Cross-Sectional Studies
Diffusion Tensor Imaging methods
Female
Humans
Longitudinal Studies
Male
Middle Aged
Reproducibility of Results
Cerebral Small Vessel Diseases diagnostic imaging
Cerebral Small Vessel Diseases pathology
Cerebral Small Vessel Diseases physiopathology
Cognitive Dysfunction diagnostic imaging
Cognitive Dysfunction pathology
Cognitive Dysfunction physiopathology
Connectome standards
Default Mode Network diagnostic imaging
Default Mode Network pathology
Default Mode Network physiopathology
Diffusion Tensor Imaging standards
Nerve Net diagnostic imaging
Nerve Net pathology
Nerve Net physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0193
- Volume :
- 41
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Human brain mapping
- Publication Type :
- Academic Journal
- Accession number :
- 32087047
- Full Text :
- https://doi.org/10.1002/hbm.24967