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Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice.
- Source :
-
Diabetes [Diabetes] 2020 May; Vol. 69 (5), pp. 927-939. Date of Electronic Publication: 2020 Feb 21. - Publication Year :
- 2020
-
Abstract
- Vitamin D deficiency has been associated with increased incidence of diabetes, both in humans and in animal models. In addition, an association between vitamin D receptor (VDR) gene polymorphisms and diabetes has also been described. However, the involvement of VDR in the development of diabetes, specifically in pancreatic β-cells, has not been elucidated yet. Here, we aimed to study the role of VDR in β-cells in the pathophysiology of diabetes. Our results indicate that Vdr expression was modulated by glucose in healthy islets and decreased in islets from both type 1 diabetes and type 2 diabetes mouse models. In addition, transgenic mice overexpressing VDR in β-cells were protected against streptozotocin-induced diabetes and presented a preserved β-cell mass and a reduction in islet inflammation. Altogether, these results suggest that sustained VDR levels in β-cells may preserve β-cell mass and β-cell function and protect against diabetes.<br /> (© 2020 by the American Diabetes Association.)
- Subjects :
- Animals
Blood Glucose
Diabetes Mellitus
Diabetes Mellitus, Experimental
Female
Gene Expression Regulation drug effects
Gene Expression Regulation physiology
Glucose administration & dosage
Glucose pharmacology
Insulin-Like Growth Factor II genetics
Male
Mice
Mice, Inbred NOD
Mice, Transgenic
Receptors, Calcitriol genetics
Insulin-Like Growth Factor II metabolism
Insulin-Secreting Cells metabolism
Receptors, Calcitriol metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1939-327X
- Volume :
- 69
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 32086292
- Full Text :
- https://doi.org/10.2337/db19-0757