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Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews.
- Source :
-
Scientific reports [Sci Rep] 2020 Feb 20; Vol. 10 (1), pp. 3116. Date of Electronic Publication: 2020 Feb 20. - Publication Year :
- 2020
-
Abstract
- The recommended antiviral drugs available for the treatment and prevention of influenza are neuraminidase inhibitors (NAIs). The aim of this study was to evaluate age-related clinical manifestations of adverse events (AEs) related to NAIs. FAERS and WebMD data were downloaded. The available NAIs selected for the analysis were oseltamivir, peramivir, zanamivir, and laninamivir. Disproportionality was analyzed using the proportional reporting ratio (PRR), the reporting odds ratio (ROR), and the information component (IC) methods. In total, 16729 AEs from 4598 patients and 575 AEs from 440 patients in the FAERS and WebMD, respectively, were included in the analysis. In the FAERS, AEs were more common among those who were younger (<19 years) for zanamivir, while for those who were older (>65 years) for peramivir. A disproportionality analysis showed that signals for vomiting and hallucinations were detected in younger patients given oseltamivir, while an abnormal hepatic function, cardiac failure, shock, and cardio-respiratory arrest were detected in older patients given peramivir. Psychiatric disorders were most common in younger and older patients, while gastrointestinal disorders were most common in adult given oseltamivir in the WebMD. Adverse symptoms related to NAIs varied and depended on the drugs used and the age of the patient.
- Subjects :
- Acids, Carbocyclic adverse effects
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Female
Guanidines adverse effects
Humans
Infant
Infant, Newborn
Internet
Male
Middle Aged
Odds Ratio
Oseltamivir adverse effects
Patient Participation
Pyrans adverse effects
Risk Factors
Sialic Acids adverse effects
United States
United States Food and Drug Administration
Young Adult
Zanamivir adverse effects
Adverse Drug Reaction Reporting Systems
Antiviral Agents adverse effects
Influenza, Human drug therapy
Neuraminidase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32080337
- Full Text :
- https://doi.org/10.1038/s41598-020-60068-5