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Intravenous lidocaine affects oxaliplatin pharmacokinetics in simultaneous infusion.
- Source :
-
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners [J Oncol Pharm Pract] 2020 Dec; Vol. 26 (8), pp. 1850-1856. Date of Electronic Publication: 2020 Feb 19. - Publication Year :
- 2020
-
Abstract
- Background: Oxaliplatin is a chemotherapeutic agent used to treat malignancies of the gastrointestinal tract. Neuropathy is a frequent dose-limiting side-effect of oxaliplatin therapy, without preventive or curative strategies. Concomitant administration of intravenous lidocaine could be a promising treatment. However, the effect of intravenous lidocaine on oxaliplatin pharmacokinetics was never studied before. We evaluated the effect of lidocaine on the area under the curve and C <subscript>max</subscript> of oxaliplatin as a part of a larger study addressing the prevention and treatment of oxaliplatin induced peripheral neuropathy with lidocaine.<br />Methods: In this prospective cross-over trial, patients received an oxaliplatin cycle with and without lidocaine (bolus 1.5 mg kg <superscript>-1</superscript> followed by 1.5 mg kg <superscript>-1</superscript>  h <superscript>-1</superscript> in 3 h). Levels of oxaliplatin, measured as ultrafiltrable platinum were determined at 10 min after cessation of oxaliplatin infusion and hourly thereafter. Outcomes are the difference in area under the curve of oxaliplatin (primary) and the difference in the C <subscript>max</subscript> of oxaliplatin (secondary).<br />Results: No difference in the %Δ area under the curve of oxaliplatin (-2.40 ± 7.66, 90% CI +10.50 to -15.31) was found. However, %Δ C <subscript>max</subscript> of oxaliplatin (-28.72 ± 6.01, 90% CI -18.59 to -38.85) was lower to a statistically significant extent in the chemotherapy cycle with lidocaine. No (serious) adverse events were reported.<br />Conclusions: Lidocaine does not affect the area under the curve of oxaliplatin, which is the most important parameter in drug interaction studies and for oxaliplatin treatment effect. The lower C <subscript>max</subscript> in the chemotherapeutic cycle with lidocaine is significant and remarkable, but with an unknown exact mechanism or clinical significance, making further research desirable.
- Subjects :
- Administration, Intravenous
Antineoplastic Combined Chemotherapy Protocols adverse effects
Cross-Over Studies
Female
Humans
Male
Middle Aged
Prospective Studies
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Lidocaine administration & dosage
Neoplasms drug therapy
Oxaliplatin pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1477-092X
- Volume :
- 26
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
- Publication Type :
- Academic Journal
- Accession number :
- 32075507
- Full Text :
- https://doi.org/10.1177/1078155220905011