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Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia.
- Source :
-
Biomolecules [Biomolecules] 2020 Feb 14; Vol. 10 (2). Date of Electronic Publication: 2020 Feb 14. - Publication Year :
- 2020
-
Abstract
- Aberrant production of hydrogen sulfide (H <subscript>2</subscript> S) has been linked to preeclampsia. We hypothesized that sodium thiosulfate (STS), a H <subscript>2</subscript> S donor, reduces hypertension and proteinuria, and diminishes fetal growth restriction in the Dahl salt-sensitive (S) rat, a spontaneous model of superimposed preeclampsia. In addition to a control group (n = 13), two groups received STS via drinking water at a dose of 2 g (n = 9) or 3 g per kg body weight per day (n = 8) from gestational day (GD) 10 to 20. Uterine artery resistance index was measured (GD18), urinary protein excretion rate was determined (GD19), and blood pressure and fetal outcomes were evaluated (GD20). At 2 g, STS had no effect on preeclamptic symptoms or fetal outcome. At 3 g, STS reduced maternal hypertension (121.8 ± 3.0 vs. 136.3 ± 2.9), but increased proteinuria (89 ± 15 vs. 56 ± 5 mg/24h), and relative kidney weight (0.86 ± 0.04 vs. 0.73 ± 0.02%). Fetal/placental weight ratio was reduced (3.83 ± 0.07 vs. 4.31 ± 0.08) without affecting litter size. No differences in uterine artery flow or renal histological damage were noted across treatment groups. While these data suggest a promising antihypertensive effect that could imply prolongation of preeclamptic pregnancies, the unfavorable effects on proteinuria, kidney weight, and fetal/placental weight ratio implies that clinical implementation of STS is contra-indicated until safety for mother and child can be verified.<br />Competing Interests: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
- Subjects :
- Animals
Blood Pressure drug effects
Female
Fetal Growth Retardation metabolism
Fetus metabolism
Hypertension metabolism
Kidney metabolism
Placenta blood supply
Placenta drug effects
Placenta metabolism
Pre-Eclampsia physiopathology
Pregnancy
Proteinuria metabolism
Rats
Rats, Inbred Dahl
Thiosulfates metabolism
Uterine Artery metabolism
Pre-Eclampsia drug therapy
Pre-Eclampsia metabolism
Thiosulfates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2218-273X
- Volume :
- 10
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- 32075042
- Full Text :
- https://doi.org/10.3390/biom10020302