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Aquaporin 1, 3, and 5 Patterns in Salivary Gland Mucoepidermoid Carcinoma: Expression in Surgical Specimens and an In Vitro Pilot Study.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Feb 14; Vol. 21 (4). Date of Electronic Publication: 2020 Feb 14. - Publication Year :
- 2020
-
Abstract
- Salivary gland aquaporins (AQPs) are essential for the control of saliva production and maintenance of glandular structure. However, little is known of their role in salivary gland neoplasia. Salivary gland tumors comprise a heterogeneous group of lesions, featuring variable histological characteristics and diverse clinical behaviors. Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. The aim of this study was to evaluate the expression of AQP1, AQP3, and AQP5 in 24 MEC samples by immunohistochemistry. AQP1 expression was observed in vascular endothelium throughout the tumor stroma. AQP3 was expressed in epidermoid and mucosal cells and AQP5 was expressed in mucosal cells of MEC. These proteins were expressed in the human MEC cell line UH-HMC-3A. Cellular ultrastructural aspects were analyzed by electron microscopy to certificate the tumor cell phenotype. In summary, our results show that, despite the fact that these molecules are important for salivary gland physiology, they may not play a distinct role in tumorigenesis in MEC. Additionally, the in vitro model may offer new possibilities to further investigate mechanisms of these molecules in tumor biology and their real significance in prognosis and possible target therapies.
- Subjects :
- Adult
Carcinoma, Mucoepidermoid metabolism
Carcinoma, Mucoepidermoid mortality
Cell Line, Tumor
Epithelial Cells pathology
Epithelial Cells ultrastructure
Female
Humans
Immunohistochemistry
Male
Microscopy, Electron
Middle Aged
Phenotype
Pilot Projects
Salivary Gland Neoplasms metabolism
Salivary Gland Neoplasms mortality
Survival Rate
Aquaporin 1 metabolism
Aquaporin 3 metabolism
Aquaporin 5 metabolism
Carcinoma, Mucoepidermoid pathology
Salivary Gland Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32075009
- Full Text :
- https://doi.org/10.3390/ijms21041287