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Quercetin/chitosan-graft-alpha lipoic acid micelles: A versatile antioxidant water dispersion with high stability.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2020 Apr 15; Vol. 234, pp. 115927. Date of Electronic Publication: 2020 Jan 31. - Publication Year :
- 2020
-
Abstract
- Natural active compounds with antioxidant properties and other potential health benefits, like quercetin (Qu), have aroused wide concern for developing bio-functional products. However, their applications are hindered by their intrinsic poor water solubility and chemical instability. In this paper, a natural antioxidant alpha lipoic acid (ALA) was grafted onto chitosan (CS) to synthesize a novel graft polymer (CS-graft-ALA). In particular, this graft-polymer could self-assemble into spherical nanomicelles in water, with a low critical micelle concentration (CMC) of 0.0076 mg/mL. As a robust and active nanocarrier, the CS-graft-ALA micelles showed high efficiency in encapsulating Qu and dispersing Qu in water. As found, the antioxidant activity of Qu was effectively enhanced when entrapped within CS-graft-ALA micelles. Moreover, CS-graft-ALA micelles could significantly improve the photo-stability and temperature-stability of Qu. The Qu/CS-graft-ALA micelles with excellent water dispersability, stability and improved antioxidant activity hold a great potential for wide applications.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antioxidants chemical synthesis
Antioxidants chemistry
Biphenyl Compounds antagonists & inhibitors
Chitosan chemistry
Micelles
Molecular Structure
Particle Size
Picrates antagonists & inhibitors
Polymers chemical synthesis
Polymers chemistry
Quercetin chemistry
Solubility
Surface Properties
Thioctic Acid chemistry
Water chemistry
Antioxidants pharmacology
Chitosan pharmacology
Polymers pharmacology
Quercetin pharmacology
Thioctic Acid pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 234
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 32070546
- Full Text :
- https://doi.org/10.1016/j.carbpol.2020.115927