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Prevalence of human papillomavirus in archival head and neck cancer in the eastern Inner Mongolian Autonomous Region, China.
- Source :
-
Tumori [Tumori] 2020 Oct; Vol. 106 (5), pp. 369-377. Date of Electronic Publication: 2020 Feb 17. - Publication Year :
- 2020
-
Abstract
- Objective: To investigate the prevalence of human papillomavirus (HPV) in archival head and neck cancer (HNC) collected from the Tong-Liao area, which is located in east Inner Mongolia, China.<br />Methods: The presence of HPV in 54 HNCs and 25 benign biopsies was detected and the sequence variation of the E6 gene in HPV-positive samples was analyzed to determine their lineage/sublineage classification.<br />Results: HPV was detected in only 4 out of 54 HNCs and no benign biopsies were found to be HPV-positive. After further p16 <superscript>INK4a</superscript> immunostaining, only 3 cases of HNC were positive for both HPV and p16 <superscript>INK4a</superscript> . Phylogenetic analysis of the isolated E6 gene shows that the HPV 16, HPV 31, and HPV 58 isolated in this study belong to lineage A.<br />Conclusions: The prevalence of HPV in HNC from this area is very low. The lineage/sublineage classification of the 3 HPV types in HNC in this area is consistent with the previous reported data of HPV lineage distribution in cervical cancer within China.
- Subjects :
- Adult
Aged
China epidemiology
DNA, Viral genetics
DNA, Viral isolation & purification
Female
Head and Neck Neoplasms epidemiology
Head and Neck Neoplasms genetics
Head and Neck Neoplasms pathology
Human papillomavirus 16 isolation & purification
Human papillomavirus 16 pathogenicity
Human papillomavirus 31 isolation & purification
Human papillomavirus 31 pathogenicity
Humans
Male
Middle Aged
Neoplasms genetics
Neoplasms pathology
Neoplasms virology
Papillomaviridae pathogenicity
Papillomavirus Infections genetics
Papillomavirus Infections pathology
Phylogeny
Cyclin-Dependent Kinase Inhibitor p16 genetics
Head and Neck Neoplasms virology
Papillomaviridae isolation & purification
Papillomavirus Infections virology
Subjects
Details
- Language :
- English
- ISSN :
- 2038-2529
- Volume :
- 106
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Tumori
- Publication Type :
- Academic Journal
- Accession number :
- 32066343
- Full Text :
- https://doi.org/10.1177/0300891620901768