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Tuning T helper cell differentiation by ITK.
- Source :
-
Biochemical Society transactions [Biochem Soc Trans] 2020 Feb 28; Vol. 48 (1), pp. 179-185. - Publication Year :
- 2020
-
Abstract
- CD4+ effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In this review we discussed the role that signals downstream of ITK, including the Ras/MAPK pathway, play in differentially controlling the differentiation of TH17, Foxp3+ T regulatory (Treg) cells, and Type 1 regulatory T (Tr1) cells, supporting a model of ITK signals controlling a decision point in the effector T cell differentiation process.<br /> (© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.)
- Subjects :
- Animals
Cytokines metabolism
Forkhead Transcription Factors metabolism
Humans
Lymphocyte Activation immunology
Mice
Protein-Tyrosine Kinases metabolism
Receptors, Antigen, T-Cell metabolism
Signal Transduction immunology
T-Lymphocytes, Regulatory immunology
Th17 Cells metabolism
Cell Differentiation immunology
Protein-Tyrosine Kinases immunology
Th17 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1470-8752
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical Society transactions
- Publication Type :
- Academic Journal
- Accession number :
- 32049330
- Full Text :
- https://doi.org/10.1042/BST20190486