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Chronic kidney disease attenuates the impact of obesity on quality of life.

Authors :
Suh SH
Choi HS
Kim CS
Bae EH
Ma SK
Lee DH
Kim SW
Source :
Scientific reports [Sci Rep] 2020 Feb 11; Vol. 10 (1), pp. 2375. Date of Electronic Publication: 2020 Feb 11.
Publication Year :
2020

Abstract

The impact of obesity on health-related quality of life (HRQoL) in chronic kidney disease (CKD) population has not been elucidated, despite the impairment of HRQoL in the obese among general population. We hypothesized that the impact of obesity on HRQoL might be confounded by impaired renal function in CKD population, and that CKD would attenuate the impact of obesity on HRQoL. To compare the impact of obesity on HRQoL according to kidney function, 17,001 subjects from Korea National Health and Nutrition Examination Survey (2008-2011) were categorized by estimated glomerular filtration rate (eGFR), as follows: group 1, eGFR ≥ 90 mL/min/1.73 m <superscript>2</superscript> ; group 2, eGFR of 60-89 mL/min/1.73 m <superscript>2</superscript> ; group 3, eGFR < 60 mL/min/1.73 m <superscript>2</superscript> . The association between obesity parameters (body mass index, waist circumference and, truncal fat mass) and HRQoL parameters (EQ-5D index and EQ-VAS) were cross-sectionally analyzed. Despite robust correlations between obesity parameters and low EQ-5D index or EQ-VAS in general population, no significant association was observed in group 3 population. Impact of obesity on HRQoL in CKD population was only limitedly observed in the mobility domain of EQ-5D, as mobility limitation was associated with increased body mass index or waist circumference regardless of kidney function. Therefore, the impact of obesity on HRQoL seems significantly attenuated in CKD population, suggesting that the risk of obesity should not be over-estimated in patients with CKD, especially with respect to HRQoL.

Details

Language :
English
ISSN :
2045-2322
Volume :
10
Issue :
1
Database :
MEDLINE
Journal :
Scientific reports
Publication Type :
Academic Journal
Accession number :
32047200
Full Text :
https://doi.org/10.1038/s41598-020-59382-9